Second neoplasms after cancers of unknown primary

Burden of malignancy after a primary skin cancer: recurrence, multiple skin cancers and second primary cancers.

The current paper summarizes relevant recent research on the high risk of recurrence, multiple skin cancers and second primary cancers in the growing number of people with a history of skin cancer; the ultimate purpose is to better assess the burden of malignancy following skin cancer. A number of challenges exist in identifying and tracking both melanoma and non-melanoma skin cancer (NMSC) cas...

Second primary cancers after sporadic and familial colorectal cancer.

Second cancers were studied among 68,104 cases of colorectal cancer (CRC) from the Swedish Family-Cancer Database. A total of 1,113 patients received a diagnosis of second CRC; 25 of them had a family history of CRC. Cases of second CRC with a family history were diagnosed up to 10 years before sporadic cases. The relative risk (RR) of all second CRCs was 2.21 compared with the first CRC. Famil...

Prediction of Primary Tumors in Cancers of Unknown Primary.

A cancer of unknown primary (CUP) is a metastatic cancer for which standard diagnostic tests fail to identify the location of the primary tumor. CUPs account for 3-5% of cancer cases. Using molecular data to determine the location of the primary tumor in such cases can help doctors make the right treatment choice and thus improve the clinical outcome. In this paper, we present a new method for ...

Risk of second cancers in chronic myeloproliferative neoplasms.

We read with interest the article by Frederiksen et al about the increased risk of developing hematologic and nonhematologic cancers in a large cohort of Danish patients with myeloproliferative neoplasms (MPNs).1 In a previous study2 we reported that MPN patients have a 3.44-fold higher risk of lymphoid neoplasms compared with the general population, in line with current1 and other results.3 Co...

A primary approach to cancers of unknown primary.